The Kidney Chronicles: A Pediatric Nephrology Podcast

Episode 18: Applying to Pediatric Nephrology Fellowship

Join us for this special episode regarding how to apply for pediatric nephrology fellowship. We will give residents the inside scoop on succeeding in landing their top match in the application and interview process! Guests on this podcast are pediatric nephrology program directors- Drs. Erum Hartung (CHOP), Julie Goodwin (Yale), Elizabeth Ingulli (UCSD/Rady Children's), Carla Nester (University of Iowa) and current pediatric nephrology fellows- Emily Zangla (University of Minnesota), Carlos Becerril-Romero (Lurie Children's), Emilia Cadiz (Emory), Uche Nwaogazie (CHOP), and Kelly Garrity (UCLA).
Questions? Reach out to Emily at doctoremilyz@gmail.com 
 

Episode 17: Neonatal Dialysis

Join us for the discussion on neonatal dialysis with expert Dr. David Askenazi from the University of Alabama who pioneered the adaptation of the Aquadex machine to infants!
 
We cover acute kidney injury, the utilization of peritoneal dialysis, CRRT, Aquadex and Carpediem in neonates and the logistics behind the use of these novel new machines. 
 
To get involved, visit the Neonatal Kidney Collaborative website at: https://babykidney.org/ 
High-yield papers on neonatal AKI and dialysis:
AWAKEN Study: https://pubmed.ncbi.nlm.nih.gov/29732396/
Aquapheresis case series in children: https://pubmed.ncbi.nlm.nih.gov/31462396/ 
CRRT vs. Carpediem outcomes: https://pubmed.ncbi.nlm.nih.gov/34414499/ 

Episode 16: The Golden Age of Lupus Nephritis

Dr. Brad Rovin, director of the Division of Nephrology and the Vice Chair of Research in Internal Medicine at the Ohio State University, discusses recent advances in lupus nephritis treatment. Dr. Rovin is deputy editor of Kidney International and the co-chair of glomerular disease guidelines for KDIGO. He has published many major landmark nephrology clinical trials in lupus nephritis (listed below), which he highlights in this episode. It's the "golden age" of lupus nephritis treatment! 
Papers we discuss:
BLISS (Belimumab) https://www.nejm.org/doi/full/10.1056/NEJMoa2001180 
AURORA (Voclosporin) https://www.thelancet.com/article/S0140-6736(21)00578-X/fulltext 
LUNAR (Rituximab) https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.34359 
NOBILITY (Obinutuzumab) https://ard.bmj.com/content/81/1/100 
TULIP-LN (Anifrolumab) https://ard.bmj.com/content/81/4/496 
Also check out https://kidney.wiki/ pediatric nephrology platform created by Ryan Town, a fellow from Stanford! 
 

Episode 15: Everything You Need to Know About Membranous Nephropathy

(*OK, maybe not EVERYTHING, but a very thorough and worthwhile review!)
Dr. Michelle O'Shaughnessy, a consultant nephrologist at Galway University Hospitals in Ireland, and Dr. Tiffany Caza, a renal pathologist at Arkana Labs, give us the high-yield points on membranous nephropathy, in both pediatric and adult patients! They are both well published and have excellent clinical experiences to share with listeners. 
Check out Michelle's Cure GN paper on membranous treatment in children: https://pubmed.ncbi.nlm.nih.gov/31844809/ 
Check out Tiffany's newest paper on novel membranous antigens: https://pubmed.ncbi.nlm.nih.gov/36638888/ 

Episode 14: Neurodevelopment in Pediatric CKD

Dr. Lyndsay Harshman, an Associate Professor of Pediatric Nephrology and Director of the Pediatric Kidney Transplantation Program at the University of Iowa, explains how and why kids with chronic kidney disease have different brain structures and cognitive abilities, compared to their healthy peers. She discusses her research discoveries regarding brain imaging in kids with CAKUT and shares her tips so that clinicians can best help their at-risk patients. 
 
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Episode 13: IgA Nephropathy

Dr. Brad Rovin, director of the Division of Nephrology and the Vice Chair of Research in Internal Medicine at the Ohio State University, discusses IgA nephrology. Dr. Rovin is deputy editor of Kidney International and the co-chair of glomerular disease guidelines for KDIGO. He has published many major landmark nephrology clinical trials, including the BLISS and AURORA trials in lupus nephritis and the NefIgArd targeted-release budesonide trial in IgA nephropathy, which he highlights in this podcast.
Links to mentioned publications in this episode: 
BLISS https://www.nejm.org/doi/10.1056/NEJMoa2001180?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
AURORA https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00578-X/fulltext 
TESTING https://jamanetwork.com/journals/jama/fullarticle/2792252   NefIgArd https://www.kidney-international.org/article/S0085-2538(22)00836-5/fulltext  
Meta-analysis SGLT2 inhibitors https://www.thelancet.com/action/showPdf?pii=S0140-6736%2822%2902074-8 
 
 

Episode 12: Sickle Cell Nephropathy

Dr. Marianne Yee, a pediatric hematologist at Emory, and Dr. Rima Zahr, a pediatric nephrologist at the University of Tennessee, share their clinical pearls regarding sickle cell disease and its subsequent kidney involvement. These experts bring up excellent points of discussion including albuminuria screening, hyperfiltration injury, the role of a kidney biopsy, papillary necrosis, nocturnal hypertension, kidney transplant outcomes, renal medullary carcinoma and health disparities that these patients face. This episode is helpful for both pediatric and adult nephrologists, primary care providers and hematologists! 
Check out these high-yield publications:
Genetics of medullary carcinoma: https://pubmed.ncbi.nlm.nih.gov/34261517/
Sickle cell ESRD patient disparities: https://pubmed.ncbi.nlm.nih.gov/36191963/
Pediatric sickle cell kidney biopsy findings: https://pubmed.ncbi.nlm.nih.gov/30945006/
Losartan for sickle cell albuminuria: https://pubmed.ncbi.nlm.nih.gov/28951038/
CKD and albuminuria prevalence in pediatric sickle cell disease: https://pubmed.ncbi.nlm.nih.gov/21940843/

Episode 11: Hyperkalemia and Hyperphosphatemia

Dr. Michael Bernaba, a Mayo Clinic adult nephrology fellow, Paige Balgie, RD, LD who specializes in pediatric nephrology nutrition at the University of Minnesota and Dr. Chelsey Jensen, PharmD, who has special expertise in pediatric transplant and nephrology patients at the University of Minnesota discuss how to deal with hyperkalemia and hyperphosphatemia. We discuss renal-friendly infant formula,  clinical tricks from our friendly nutritionist and pharmacist and the different approaches adult versus pediatric providers take in regards to binders to deal with these pesky problems. 
 
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Episode 10: Maintenance Intravenous Fluids, Part 2

This is a continuation of September's episode 9. Dr. Michael Mortiz and Dr. Carlos Ayus take us through the history of intravenous fluids in children with the discovery of SIADH and the life-threatening hyponatremic encephalopathy cases that lead to a change in practice with the use of normal saline.
 
Dr. Mortiz is the director pediatric nephrology, along with the dialysis and transplant programs at UPMC Children’s Hospital of Pittsburgh. He most notably published the 2018 AAP Clinical Practice Guideline: Maintenance Intravenous Fluids in Children. Dr. Ayus is an adult nephrologist and professor of medicine at UC Irvine with an interest in electrolyte disorders. He has trained, and worked with, founding fathers of both pediatric and adult nephrology, such as Drs. Floyd Rector and Malcolm Holliday.
 
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Episode 9: Maintenance Intravenous Fluids, Part 1

Dr. Michael Mortiz and Dr. Carlos Ayus take us through the history of intravenous fluids in children with the discovery of SIADH and the life-threatening hyponatremic encephalopathy cases that lead to a change in practice with the use of normal saline.
 
Dr. Mortiz is the director pediatric nephrology, along with the dialysis and transplant programs at UPMC Children’s Hospital of Pittsburgh. He most notably published the 2018 AAP Clinical Practice Guideline: Maintenance Intravenous Fluids in Children. Dr. Ayus is an adult nephrologist and professor of medicine at UC Irvine with an interest in electrolyte disorders. He has trained, and worked with, founding fathers of both pediatric and adult nephrology, such as Drs. Floyd Rector and Malcolm Holliday.
 
Don’t miss out on an inside glimpse into how these experts managed to overturn popular opinion and accepted concepts in the field of nephrology during the last 20 years in order to save lives! This podcast is relevant to ANY PROVIDER who is administering IV fluids to hospitalized patients.
 
Questions/comments/feedback?? Email doctoremilyz@gmail.com.