The Kidney Chronicles: A Pediatric Nephrology Podcast

Episode 28: Calcium and phosphorus disorders

Dr. Clemens Bergwitz, an associate professor of endocrinology at Yale University, walks us through how to work-up and treat patients with calcium and phosphorus disorders. He helped to discover the disease HHRH (hereditary hypophosphatemic rickets with hypercalciuria) and has wonderful knowledge to share with listeners regarding the bone-mineral axis! 
 
References
2024 KIR Update on HHRH https://pubmed.ncbi.nlm.nih.gov/38364990/ 
2009 Ped Nephrology Genetic causes of hypercalciuric nephrolithiasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770137/ 
TMP calculation and reference ranges https://www.nbt.nhs.uk/sites/default/files/Protocol%20for%20measurement%20of%20TmP.pdf 

Episode 27: Hyperoxaluria and miscellaneous stone management

Join us to learn about hyperoxaluria from nephrolithiasis expert and division director of pediatric nephrology at Mayo Clinic, Dr. David Sas! We discuss pathophysiology, work-up and management of primary hyperoxaluria, including new game-changing therapies. Dr. Sas also answers other high-yield kidney stone management questions. 
 
Resources:
Novodetect primary hyperoxaluria/nephrolithiasis genetic panel testing: file:///Users/student/Downloads/BpG_GTP-for-NovoDetect-Panels-Form_GTP-NVDT-2P-B.pdf
 
Rare Kidney Stone Consortium (RKSC): 800-270-4637 or rarekidneystones@mayo.edu
Resources for physicians and patients regarding all forms of rare kidney stone diseases
 
Oxalosis and Hyperoxaluria Foundation (OHF): www.ohf.org
Resources for patients, parents, and physicians regarding primary hyperoxaluria

Episode 26: SGLT-2 Inhibitors

Dr. Laura Hesemann, a med/peds-trained adult and pediatric nephrologist and Chair of Pediatrics at the University of Missouri, shares her expertise about SGLT-2 inhibitors and their utility in clinical practice.

Episode 25: Pediatric dialysis directorship

Drs. Donna Claes, Vivian Shih and Annie Kouri (our co-host) discuss their roles as pediatric dialysis directors at their institutions. Donna Claes is an associate professor of pediatric nephrology and chronic dialysis director at Cincinnati Children's and Vivian Shih is an assistant professor of pediatric nephrology and acute dialysis director at Children's Hospital Colorado. We talk about the road to becoming a dialysis director, what the job entails, the challenges, the rewarding aspects of the job and tips for those who are considering stepping into this position at their institution. 

Episode 24: Post-transplant FSGS Recurrence

Dr. Katherine Twombley, professor and chief of pediatric nephrology at the Medical University of South Carolina, shares her knowledge on FSGS recurrence after transplant. She discusses the diseases that cause FSGS and her strategy for managing these complex patients. Dr. Twombley is the director of dialysis and kidney transplantation, and does clinical research in the area of transplant. She is involved with leadership roles both in ASPN and AST.
If you have any feedback or would like to come onto the podcast, please email doctoremilyz@gmail.com

Episode 23: Transplant Directorship

As part of the leadership series of podcast episodes, this episode discusses life as a pediatric kidney transplant director. Dr. Jodi Smith, Seattle Children's transplant director and ASPN president, Dr. Gina Barletta, Phoenix Children's transplant director, and Dr. Sarah Kizilbash, co-host and University of Minnesota transplant director, talk about why and how they got to be transplant director, their program's structure, strengths, weaknesses and the greatest joys of their job. 
For more information about the ASPN transplant interest group, check out this link https://aspneph.org/transplant-interest-group/ or email jodi.smith@seattlechildrens.org
For information about UNOS, check out the calendar of events https://optn.transplant.hrsa.gov/news/calendar-of-events/ 
For UNOS requirements to become a transplant physician, check out this link https://optn.transplant.hrsa.gov/media/2785/membership_requirements-for_pediatric_components.pdf 

Episode 22: Leadership from Academia to Pharma

Join us in our discussion with Dr. Deepa Chand, who is a pediatric nephrologist, former dialysis and division director, and now director of patient safety in immunology at Novartis. She also continues to practice pediatric nephrology at the University of Illinois-Peoria. She talks about her journey to where she is today, behind-the-scenes information regarding drug development and approval, and provides practical advice that is valuable for clinicians and researchers alike.  

Episode 21: Division Directorship

This is the first episode in our leadership series! We talk with Drs. Sudha Garimella, associate professor of pediatrics at Prisma Health, and Priya Verghese, professor of pediatrics at Lurie Children's/Northwestern University about their roles as division directors in pediatric nephrology. They discuss their career paths, challenges and rewards of the job, tips for recruitment and general leadership advice, helpful for all pediatric nephrologists! 
 
ASNP

Episode 20: Post-Transplant Lymphoproliferative Disorders

Dr. Vikas Dharnidharka, Professor of Pediatrics and Pediatric Nephrology Division Director at Washington University School of Medicine in St. Louis, shares his extensive knowledge on PTLD (post-transplant lymphoproliferative disorders) in pediatric kidney transplant recipients. He is the first author of a PTLD textbook (https://link.springer.com/book/10.1007/978-3-030-65403-0) and has published numerous studies and guideline recommendations on the subject. We discuss the pathophysiology, risk factors, clinical presentation, work-up, treatment and prognosis of PTLD in this episode.
References
North American Pediatric Renal Trials and Collaborative Studies Registry (NAPRTCS) and Pediatric Nephrology Research Consortium (PNRC) studies regarding the advantages of lower dose thymoglobulin induction therapy in kidney transplantation
https://pubmed.ncbi.nlm.nih.gov/32903852/
https://pubmed.ncbi.nlm.nih.gov/33912749/
International Pediatric Transplant Association (IPTA) PTLD guidelines
https://pubmed.ncbi.nlm.nih.gov/36369733/
https://pubmed.ncbi.nlm.nih.gov/36369745/
https://pubmed.ncbi.nlm.nih.gov/37294621/
 

Episode 19: IgA Nephropathy- Adult versus Pediatric Perspectives

We have two fantastic Canadian guest nephrologists discussing IgA nephropathy on this episode. Dr. Sean Barbour is an adult nephrologist and associate professor at the University of British Columbia. He is a glomerulonephritis and epidemiology expert and serves as the chair of the British Columbia GN Committee and Registry. He developed and validated the IgA clinical prediction tool for both adults and children and has participated in the TESTING and NefIgArd clinical trials. Dr. Alexandra Cambier is a clinician-scientist and an associate professor of pediatric nephrology at Montreal University. She also worked on the pediatric IgA prediction tool and has numerous publications regarding biomarkers and genetic variants in children with IgA nephropathy. 
Publications that we discuss in this episode-
IgA prediction tool validation:
https://pubmed.ncbi.nlm.nih.gov/30980653/ https://pubmed.ncbi.nlm.nih.gov/35490842/
https://pubmed.ncbi.nlm.nih.gov/33220356/
 
CD89 in childhood IgA nephropathy:
https://pubmed.ncbi.nlm.nih.gov/34756952/
 
IgA nephropathy therapies in children:
https://pubmed.ncbi.nlm.nih.gov/34756952/
 
Targeted-release budesonide in adults with IgA nephropathy:
https://pubmed.ncbi.nlm.nih.gov/36270561/